解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Abnormal nuclear megakaryocytic staining for phospho-STAT5 (pSTAT5) correlates with JAK2 V617F mutational status in non-chronic myelogenous leukemia chronic myeloproliferative disorders. However, a proportion of wild-type JAK2 non-chronic myelogenous leukemia chronic myeloproliferative disorders cases also demonstrate...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.034
更新日期:2008-07-01 00:00:00
abstract::Only 8 cases of hamartomas of mature cardiac myocytes have been reported. The aim of the study was to describe 7 new cases and provide clinicopathologic correlation. Our anatomical pathology database was searched for all cases of cardiac hamartoma, of which 7 represented mature myocyte type. Medical records were revie...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.11.014
更新日期:2008-07-01 00:00:00
abstract::Breast cancer is one of the common malignant diseases among women in Japan as well as in western countries, and its incidence continues to increase. Normal mammary duct epithelial cells exhibit a well-organized apicobasal polarity, which forms the basis for their specific structure and function. Although the loss of e...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.11.001
更新日期:2008-06-01 00:00:00
abstract::ATP-binding cassette (ABC) multidrug transporters have been associated with chemoresistance, which is a major obstacle in attempts to improve clinical outcome of patients with nasopharyngeal carcinoma (NPC). In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.009
更新日期:2008-06-01 00:00:00
abstract::Breast cancer is the leading form of cancer diagnosed in women, and the second leading cause of cancer mortality in this group. A commonly accepted grading system for breast cancer that has proven useful for guiding treatment strategy is the modified Bloom-Richardson system. However, this system is subject to interobs...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.001
更新日期:2008-05-01 00:00:00
abstract::Morphological discrimination of urothelial carcinoma (UC) in situ, a precursor of high-grade invasive carcinoma, from severe reactive atypia is essential, but can be challenging at times. Mutations of the cell cycle regulatory gene INK4a (located at 9p21) that encodes p16(INK4) are one of the critical early events in ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.08.005
更新日期:2008-04-01 00:00:00
abstract::The proliferation marker mitotic activity index is the strongest prognostic indicator in lymph node-negative breast cancer. The World Health Organization (WHO) 2003-defined procedure for determining WHO-mitotic activity index is often replaced by a quick scan mitotic impression. We evaluated the prognostic consequence...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2007.08.016
更新日期:2008-04-01 00:00:00
abstract::To ensure appropriate mission-based budgeting and equitable distribution of funds for faculty salaries, our compensation committee developed a pathology-specific effort reporting database. Principles included the following: (1) measurement should be done by web-based databases; (2) most entry should be done by departm...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.10.033
更新日期:2008-04-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) typically affects male smokers older than 55 years. Recently, an increase in the incidence of HNSCC in young adults has been recognized, many of them nonsmokers and females. Functional inactivation of p16 is known to be a common event in HNSCC, mainly by either deletion or...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.08.004
更新日期:2008-03-01 00:00:00
abstract::Both individual patient treatment and cancer registries depend on adequate histopathology reports. To ensure the quality of these reports, professional organizations have published guidelines on minimum data sets for various cancer types. Norway has a population of 4.6 million, and all individuals have a unique identi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.06.019
更新日期:2008-03-01 00:00:00
abstract::Glypican 3 is a heparin sulfate proteoglycan bound to the cell surface that is theorized to participate in cell signaling, resulting in embryonic cell growth and differentiation. The GPC3 gene is mutated in Simpson-Golabi-Behmel syndrome, whose features include numerous developmental abnormalities, tissue overgrowth, ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.06.006
更新日期:2008-02-01 00:00:00
abstract::CpG island methylator phenotype (CIMP) pathway in colorectal cancer is characterized by methylation of promoter regions of multiple putative tumor suppressor genes. Aberrant methylation also occurs in serrated and adenomatous polyps. We examined 32 tubulovillous/villous adenomas and 30 tubular adenomas for BRAF/KRAS m...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.06.002
更新日期:2008-01-01 00:00:00
abstract::Papillary renal cell carcinoma (PRCC), a morphologically and genetically distinct subtype of RCC, is morphologically separated into 2 subtypes, type 1 and 2, for prognostic purposes. Type 1 PRCC (single layer of small cells, scant pale cytoplasm) is more common and has a favorable prognosis compared with type 2 (pseud...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.05.016
更新日期:2008-01-01 00:00:00
abstract::Congenital cystic airway malformation/congenital pulmonary airway malformation (CCAM/CPAM) of the lung is a rare but well-described malformative lesion of pulmonary parenchyma characterized by the abnormal maturation of airways along with an increase in terminal respiratory structures, resulting in cysts of variable s...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.04.009
更新日期:2007-12-01 00:00:00
abstract::We examined the effect of lateral spatial resolution and reader specialty on the accuracy of detection of breast cancer. The motivation for this pilot study was the need to acquire and display very large data sets in whole-specimen 3D digital breast histopathology imaging. The ultimate goal is to determine the minimum...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.04.006
更新日期:2007-12-01 00:00:00
abstract::Overexpression of the Eph receptor tyrosine kinases in cancers is related to malignant transformation, metastasis, tumor differentiation, and prognosis. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. In the present study, expression of EphA7 in gastric cancer cell lines ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.01.030
更新日期:2007-11-01 00:00:00
abstract::The LKB1 tumor suppressor gene codes for a serine/threonine protein kinase, and among its substrates is the adenosine monophosphate-dependent protein kinase, a sensor of intracellular energy levels. LKB1 is genetically inactivated in several types of tumors, especially lung adenocarcinomas. Here we used immunohistoche...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.01.022
更新日期:2007-09-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a member of the human herpesvirus family that was initially isolated from a cultured Burkitt lymphoma cell line by Epstein et al in 1964. Subsequent studies have proven that it is the causative agent in most cases of infectious mononucleosis. Primary infection is usually asymptomatic in chi...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2007.05.020
更新日期:2007-09-01 00:00:00
abstract::Fluorescence in situ hybridization, loss of heterozygosity testing, and comparative genomic hybridization have been used to detect NF2 gene alterations in both sporadic and neurofibromatosis type 2 (NF2)-associated central nervous system tumors. In this study, we performed chromogenic in situ hybridization (CISH) and ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.01.027
更新日期:2007-09-01 00:00:00
abstract::The presence of positive surgical margins is a negative prognostic indicator in patients undergoing prostatectomy for prostate cancer; whether the extent of the positive margins affects the clinical outcome with regards to prostate-specific antigen (PSA) recurrence remains uncertain. We evaluated the linear extent of ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2007.01.006
更新日期:2007-08-01 00:00:00
abstract::Fluorescent (FISH) and chromogenic (CISH) in situ hybridization have recently become part of the diagnostic armamentarium of breast pathologists. HER2 gene testing by FISH and/or CISH has become an integral part of the diagnostic workup for patients with breast cancer. In this era of high throughput technologies, thes...
journal_title:Human pathology
pub_type: 杂志文章,评审
doi:10.1016/j.humpath.2007.04.011
更新日期:2007-08-01 00:00:00
abstract::We report the molecular characterization of 8 primary gastric carcinomas, corresponding xenografts, and 2 novel gastric carcinoma cell lines. We compared the tumors and cell lines, with respect to histology, immunohistochemistry, copy number, and hypermethylation of up to 38 genes using methylation-specific multiplex ...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.12.010
更新日期:2007-06-01 00:00:00
abstract::An immunohistochemical survey of X-linked inhibitor of apoptosis (XIAP) expression in mammary carcinoma was performed. XIAP, the most potent of the inhibitor of apoptosis family of caspase inhibitors, has been linked to tumor aggressiveness and therapeutic resistance in several malignancies and is considered an attrac...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.016
更新日期:2007-06-01 00:00:00
abstract::Hepatoid adenocarcinoma is an extrahepatic tumor characterized by morphological similarities to hepatocellular carcinoma. The lesions contain a tubular adenocarcinoma that seems to develop "hepatoid" features, but the relation between the tubular adenocarcinomatous and the hepatoid components remains unclear. We compa...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.10.020
更新日期:2007-06-01 00:00:00
abstract::Sessile serrated adenomas and traditional serrated adenomas are pathogenetically related to inhibition of apoptosis. Survivin and hedgehog proteins, including sonic hedgehog, patched, and smoothened, inhibit apoptosis, with hedgehog proteins forming a signal transduction cascade implicated in digestive cancers. This s...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.12.004
更新日期:2007-05-01 00:00:00
abstract::Selective expression of certain chemokine receptors by melanoma cells and the presence of their ligands in tissues might govern organ site-specific metastasis. Because the expression profile of chemokine receptors in tissues of melanocytic origin is unknown, we performed a comprehensive study on melanocytic tissue sam...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.013
更新日期:2007-05-01 00:00:00
abstract::K homology domain containing protein overexpressed in cancer (KOC) is a member of the insulin-like growth factor (IGF) messenger RNA-binding protein family and is expressed during embryogenesis and in certain malignancies. KOC, known as L523S and IGF messenger RNA-binding protein 3, was shown to be frequently expresse...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.11.011
更新日期:2007-04-01 00:00:00
abstract::Cytoplasmic mislocalization of p27 (CDKN1B/KIP1) is caused by activated AKT1 and has been associated with poor prognosis in various cancers. CIMP in colorectal cancer is characterized by extensive promoter methylation and is associated with MSI-MSI-H and BRAF mutations. We have recently shown a positive correlation be...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.09.014
更新日期:2007-04-01 00:00:00
abstract::Enteroendocrine cell dysgenesis was observed in 3 patients with intestinal failure of unknown cause. Enteroendocrine cell dysgenesis is a congenitally acquired life-threatening malabsorptive condition with a unique clinical phenotype paired with a histologically identifiable disease pattern. Two cases were first prese...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.10.014
更新日期:2007-04-01 00:00:00
abstract::Plasma cells are the hallmark of chronic endometritis but are not specific for upper tract infection. Plasma cells have also been noted in hormonally mediated endometrial disorders in association with gland architectural changes ("disordered proliferative" and "anovulatory" patterns), and stromal breakdown. We reviewe...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.09.002
更新日期:2007-04-01 00:00:00
abstract::We investigated the feasibility and diagnostic agreement of a virtual slide system (VSS) in teledermatopathology. Forty-six biopsy specimens from inflammatory skin diseases were selected and scanned with a VSS at the Research Unit of Teledermatology, Medical University of Graz, Graz, Austria. Images were stored on a v...
journal_title:Human pathology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.humpath.2006.10.006
更新日期:2007-04-01 00:00:00
abstract::The Mix1 homeobox-like (MIXL1) gene encodes a paired class homeobox transcription factor that is involved in embryogenesis. Previous studies have shown that the MIXL1 gene product is expressed in B- and T-cell progenitors of normal bone marrow and, in some cell lines derived from hematopoietic neoplasms. The status of...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.09.020
更新日期:2007-03-01 00:00:00
abstract::Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma and is also associated with primary effusion lymphoma, a subset of diffuse large B-cell lymphomas, and multicentric Castleman disease. Because KSHV infection is endemic in sub-Saharan Africa, we sought to identify cases of KSHV-positive non-Hodgkin lym...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.08.009
更新日期:2007-02-01 00:00:00
abstract::The national decline in hospital autopsy cases negatively impacts physician education and medical quality control to an unknown degree. The current non-medicolegal autopsy rate is less than 5% of hospital deaths. This study compares internal medicine and pathology resident physician perceptions of the autopsy, includi...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.08.011
更新日期:2007-02-01 00:00:00
abstract::Viruses have long been held to be of pathogenetic importance in the evolution of autoimmune connective tissue disease. We describe 7 adults who developed cutaneous connective tissue disease stigmata in temporal association with recent cytomegalovirus (CMV) infection but without the classic cytopathic changes of CMV in...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.06.002
更新日期:2007-01-01 00:00:00
abstract::The objective of this study was to compare the expression of the nerve growth factor (NGF) receptors TrkA and p75 in ovarian borderline tumors, International Federation of Gynecology and Obstetrics (FIGO) stage I carcinomas and advanced-stage (FIGO stage III-IV) carcinomas, and to assess a possible association between...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.06.027
更新日期:2007-01-01 00:00:00
abstract::Annexin A1 (ANXA1) is a calcium- and phospholipid-binding protein and a known mediator of glucocorticoid-regulated inflammatory responses. Using a combined multiple high-throughput approach, we recently identified a reduced expression of ANXA1 in human breast cancer. The finding was confirmed at the gene level by quan...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.06.001
更新日期:2006-12-01 00:00:00
abstract::Heavy proteinuria after bone marrow transplantation (BMT) is rare. Pathology shows membranous glomerulonephritis (MGN) in most cases. After BMT, focal segmental glomerulosclerosis (FSGS) after resolution of MGN has not been reported. We describe a 13-year-old boy who had matched unrelated donor allogeneic BMT for rela...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.07.011
更新日期:2006-12-01 00:00:00
abstract::Semaphorins (SEMAs) compete with vascular endothelial growth factor (VEGF) for receptor neuropilin 1 (NP1) and 2 (NP2) and suppress angiogenesis. To clarify the involvement of SEMA and VEGF in the development and progression of ovarian carcinoma, we analyzed the immunohistochemical expression of SEMA, VEGF, NP1, and N...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.04.031
更新日期:2006-11-01 00:00:00
abstract::Lipomatous lesions of the heart involving the atria and interatrial septum are not well known. Most such lesions do not become clinically significant; however, intractable arrhythmias, blood flow obstruction, and valvular disruption may result from extensive fatty infiltration of the atrial wall or from the mass effec...
journal_title:Human pathology
pub_type: 杂志文章
doi:10.1016/j.humpath.2006.04.028
更新日期:2006-10-01 00:00:00